Xeomin

Xeomin (incobotulinumtoxinA) is a medication given as an injection for treating or improving the following:

• Patients 2+ years old with chronic sialorrhea
• Adults with upper limb spasticity
• Pediatric patients 2-17 years old with upper limb spasticity (except spasticity caused by cerebral palsy)
• Adults with cervical dystonia
• Adults with blepharospasm
• The appearance of moderate to severe frown lines between the eyebrows in adults with corrugator and/or procerus muscle activity

Xeomin may be given via intramuscular or intraglandular injection.

Directions

A healthcare professional will administer Xeomin intramuscularly or via intraglandular route.

Talk to your or your child’s healthcare provider about any questions or concerns you may have.

Ingredients

IncobotulinumtoxinA is the active ingredient in Xeomin.

Human albumin and sucrose are the inactive ingredients included.

Contraindications

Xeomin should not be administered to patients with an infection at the injection sites or who have an allergy to botulinum neurotoxin type A or to any of Xeomin’s excipients.

Cautions

• Xeomin is associated with the following FDA Boxed Warning:
  • Xeomin’s effects and symptoms that are consistent with botulinum toxin effects can spread from the injection site, which can occur hours to weeks after receiving the injection. Trouble swallowing and difficulty breathing can be life threatening; additionally, death can occur. Children receiving treatment for spasticity seem to be at greatest risk; however, adults may also experience symptoms, especially those who have underlying conditions that would make them more susceptible to these symptoms.
• Before you or your child starts treatment with Xoemin, inform the healthcare provider of:
  • All the medications you or your child takes, including prescription and nonprescription medications, vitamins, and supplements
  • Any allergies you or your child has
  • Any current health problems you or your child has
  • Your or your child’s past medical history
  • If you or your child is pregnant or breastfeeding
• Xeomin is associated with the following warnings and precautions:
  • Difficulty breathing, swallowing, or speaking
  • Corneal exposure and ulceration
  • Risk of ptosis, or upper eyelid drooping
  • The potency units of Xeomin are not interchangeable with other botulinum toxin products

Side Effects

The most common Xeomin side effects in:

• Adults being treated for chronic sialorrhea: tooth extraction, diarrhea, dry mouth, and high blood pressure
• Pediatric patients being treated for chronic sialorrhea: bronchitis, headache, nausea, and vomiting
• Adults being treated for upper limb spasticity: seizure, nasopharyngitis, dry mouth, and upper respiratory tract infection
• Pediatric patients being treated for upper limb spasticity: nasopharyngitis and bronchitis
• Cervical dystonia: difficulty swallowing, neck pain, muscle weakness, injection site pain, musculoskeletal pain
• Blepharospasm: eyelid drooping, dry eye, problems with vision, and dry mouth
• Frown lines between the eyebrows: headache

Tell the healthcare provider right away if you or your child experiences bothersome or persistent side effects.

Ask a healthcare provider about whether Xeomin is right for you or your child.

Reference

Xeomin. Raleigh, NC and Franksville, WI: Merz Pharmaceuticals, LLC and Merz North America, Inc.; 2023.